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http://www.sciencefriday.com/program/archives/200903275
Brain-imaging studies indicate that a thinning of the right hemisphere of the brain may be linked to an increased risk of depression. Writing in the Proceedings of the National Academy of Sciences, researchers report that people at high risk of developing depression had a 28 percent thinning of the right cortex, the brain’s outermost surface, compared to people with no known risk of depression. The thinning was not linked to actual depression — just an increased risk of developing depression. Researchers said that the discovery that there was a structural link in the cortex to depression was surprising, and plan more imaging and genetic studies to expand on the finding.
One of the interesting things I learned from this podcast, is that a lot of the research on depression has been focused on the amygdala and hippocampus–centers of emotional processing. This study was focused on the cortex … the more cognitive part of brain.
Related articles:
http://www.nytimes.com/2009/03/25/health/25brain.html?_r=1&em
“If you have thinning in this portion of the brain, it interferes with the processing of emotional stimuli,” Dr. Peterson said. “We think that’s what makes them vulnerable to developing anxiety and depression — it essentially isolates them in an emotional world.”